The Mk IV Target is the suppressor host the 10/22 can't be
Let me clear up the popular assumption first: the 10/22 is a fine rifle, and yes, it can host a suppressor just fine. But "can" and "should" are different conversations, and I've been running both platforms hard enough to tell you where the Mk IV Target wins.
The 10/22 is modular and fun, which makes it great for a lot of things. But as a dedicated suppressed .22 LR host, it's overbuilt for what matters and undercooked for what doesn't. The Mk IV Target, by contrast, was designed by someone who understood that a suppressed .22 has different requirements than an unsuppressed one.
Here's the mechanical truth: the Mk IV's bolt is naturally soft and lockback is optional. That means when you run a suppressor—especially a wet one with a few drops of oil in the baffles—you get dB reduction without fighting blowback. The first round pop sits lower because there's less gas cycling back into your face. Run the same suppressor on a 10/22 and you're fighting the bolt carrier the entire time. It works, sure. But you're not getting the cleanest baffle strike or the quietest signature the host is capable of delivering.
Accuracy is another gap. The Mk IV Target comes from the factory with a bull barrel and target sights that actually allow you to see your groups at 25 yards through a suppressor. The 10/22 doesn't; it's built for rimfire fun, not precision. If you're suppressing a .22, you're usually doing it because hearing protection matters to you—which means you probably care about shot placement, too. The Mk IV respects that math.
Maintenance tips it further. The 10/22 requires a takedown for most suppressor work. The Mk IV? Field strip the barrel in about 30 seconds. If you're running a wet suppressor, you'll want to inspect and dry your baffle stack regularly. The Mk IV lets you do that without tools.
Last point: Form 4 wait times are what they are, but once that suppressor is in your hands, you want a host that rewards the weight of that decision. The 10/22 is a rifle that makes you compromise. The Mk IV Target is a pistol that was waiting for this role the whole time.
Start with a decent 22 can—a Rugged Mask or a Saker 22 gives you real dB reduction and true suppression—and mate it to a Mk IV. You'll understand what I mean after the first magazine.
https://www.ruger.com/products/markIVTarget/specSheets/40107.html