The .45-70 subsonic problem is simpler than you think
I get asked this enough that it's worth laying out: no, a stock Marlin 1895 Guide Gun will not reliably cycle full-power subsonic .45-70 handloads. This isn't a mystery or a tuning problem—it's just physics, and the frame of the gun is what it is.
Let's start with what actually happens. A subsonic .45-70 round—say, 300 grains over enough powder to stay under 1,050 fps—produces less gas, less pressure, and less bolt thrust than a standard .45-70. The Guide Gun's lever and receiver are built around the cartridge's normal performance envelope. When you halve the muzzle velocity, you're asking a mechanism designed for full-power loads to function on a fraction of the energy it expects. The bolt doesn't travel back far enough. The carrier doesn't catch the next round. You get failures to eject and failures to feed that are predictable and repeatable—not random malfunction, but a mechanical mismatch.
This is where people often imagine they can "tune" their way through the problem. You can't. You could modify the action—lighter bolt, different spring rates, different cam geometry—but now you're rebuilding a rifle that cost $400 into something that works like a $2,000 custom build, and you've also made it dangerous to shoot full-power loads through. The math doesn't work, and the practical outcome is worse than doing nothing.
What actually does work is understanding the .300 Blackout exists for a reason. It was engineered specifically to be subsonic-capable while cycling in an AR-15. If you want a rifle that runs reliably on subsonic ammunition, that's the cartridge. If you want a .45-70, you're buying into a cartridge optimized for full-power work—and full-power .45-70 is still a legitimately useful round in a lever gun for the distances where you'd actually use it. The suppressor adds handling value regardless; you get less report even on full-power loads, which matters if you're hunting or at the range with others.
The honest caveat here is that some shooters report marginal success with reduced-power loads (still above subsonic velocity) using specific bullet weights and powder combinations. I haven't tested this myself in a Guide Gun, so I can't tell you whether that's real or confirmation bias. If you're going to chase it, load one round, hand-cycle it, load two, fire and observe what the action does—don't blame the rifle if it tells you no.
But if your goal is suppressed .45-70 and you want it to actually work, build or buy a bolt-action. Or shoot the .45-70 unsuppressed, which is already less brutal than people think.